2vin: Difference between revisions

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{{Seed}}
[[Image:2vin.png|left|200px]]
[[Image:2vin.png|left|200px]]


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{{STRUCTURE_2vin|  PDB=2vin  |  SCENE=  }}  
{{STRUCTURE_2vin|  PDB=2vin  |  SCENE=  }}  


===FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR===
===FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR===


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{{ABSTRACT_PUBMED_18163548}}
{{ABSTRACT_PUBMED_18163548}}


==About this Structure==
==About this Structure==
2VIN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIN OCA].  
[[2vin]] is a 1 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIN OCA].  
 
==See Also==
*[[Urokinase|Urokinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:18163548</ref><references group="xtra"/>
<ref group="xtra">PMID:018163548</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: U-plasminogen activator]]
[[Category: U-plasminogen activator]]
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Kringle]]
[[Category: Kringle]]
[[Category: Pharmaceutical]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Plasminogen activation]]
[[Category: Plasminogen activation]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Secreted]]
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[[Category: Urokinase-type plasminogen activator]]
[[Category: Urokinase-type plasminogen activator]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:52:16 2009''

Revision as of 08:33, 26 July 2012

File:2vin.png

Template:STRUCTURE 2vin

FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR

Template:ABSTRACT PUBMED 18163548

About this Structure

2vin is a 1 chain structure of Urokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Frederickson M, Callaghan O, Chessari G, Congreve M, Cowan SR, Matthews JE, McMenamin R, Smith DM, Vinkovic M, Wallis NG. Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem. 2008 Jan 24;51(2):183-6. Epub 2007 Dec 29. PMID:18163548 doi:https://dx.doi.org/10.1021/jm701359z

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