3ds6: Difference between revisions
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[[Image:3ds6.png|left|200px]] | [[Image:3ds6.png|left|200px]] | ||
{{STRUCTURE_3ds6| PDB=3ds6 | SCENE= }} | {{STRUCTURE_3ds6| PDB=3ds6 | SCENE= }} | ||
===P38 complex with a phthalazine inhibitor=== | ===P38 complex with a phthalazine inhibitor=== | ||
{{ABSTRACT_PUBMED_18817365}} | {{ABSTRACT_PUBMED_18817365}} | ||
==About this Structure== | ==About this Structure== | ||
[[3ds6]] is a 4 chain structure of [[Mitogen-activated protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DS6 OCA]. | |||
==See Also== | |||
*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:018817365</ref><ref group="xtra">PMID:018817364</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
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[[Category: Li, V.]] | [[Category: Li, V.]] | ||
[[Category: Syed, R.]] | [[Category: Syed, R.]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Kinase inhibitor complex]] | [[Category: Kinase inhibitor complex]] | ||
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[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 10:37, 26 July 2012
P38 complex with a phthalazine inhibitor
Template:ABSTRACT PUBMED 18817365
About this Structure
3ds6 is a 4 chain structure of Mitogen-activated protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Herberich B, Cao GQ, Chakrabarti PP, Falsey JR, Pettus L, Rzasa RM, Reed AB, Reichelt A, Sham K, Thaman M, Wurz RP, Xu S, Zhang D, Hsieh F, Lee MR, Syed R, Li V, Grosfeld D, Plant MH, Henkle B, Sherman L, Middleton S, Wong LM, Tasker AS. Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold. J Med Chem. 2008 Sep 26. PMID:18817365 doi:10.1021/jm8005417
- Pettus LH, Xu S, Cao GQ, Chakrabarti PP, Rzasa RM, Sham K, Wurz RP, Zhang D, Middleton S, Henkle B, Plant MH, Saris CJ, Sherman L, Wong LM, Powers DA, Tudor Y, Yu V, Lee MR, Syed R, Hsieh F, Tasker AS. 3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase. J Med Chem. 2008 Oct 23;51(20):6280-92. Epub 2008 Sep 26. PMID:18817364 doi:10.1021/jm8005405
