2aei: Difference between revisions

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{{Seed}}
[[Image:2aei.png|left|200px]]
[[Image:2aei.png|left|200px]]


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{{STRUCTURE_2aei|  PDB=2aei  |  SCENE=  }}  
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===Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid===
===Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid===


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{{ABSTRACT_PUBMED_16125385}}
{{ABSTRACT_PUBMED_16125385}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]]
[[2aei]] is a 3 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEI OCA].


==About this Structure==
==See Also==
2AEI is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEI OCA].
*[[Factor VIIa|Factor VIIa]]


==Reference==
==Reference==
<ref group="xtra">PMID:16125385</ref><references group="xtra"/>
<ref group="xtra">PMID:016125385</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Enzyme inhibitor complex]]
[[Category: Enzyme inhibitor complex]]
[[Category: Gla]]
[[Category: Gla]]
[[Category: Hydrolase]]
[[Category: Pyridine]]
[[Category: Pyridine]]
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Thrombosis]]
[[Category: Thrombosis]]
[[Category: Tissue factor]]
[[Category: Tissue factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:48:29 2009''

Revision as of 10:47, 26 July 2012

File:2aei.png

Template:STRUCTURE 2aei

Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid

Template:ABSTRACT PUBMED 16125385

About this Structure

2aei is a 3 chain structure of Factor VIIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Kohrt JT, Filipski KJ, Cody WL, Cai C, Dudley DA, Van Huis CA, Willardsen JA, Rapundalo ST, Saiya-Cork K, Leadley RJ, Narasimhan L, Zhang E, Whitlow M, Adler M, McLean K, Chou YL, McKnight C, Arnaiz DO, Shaw KJ, Light DR, Edmunds JJ. The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4752-6. PMID:16125385 doi:10.1016/j.bmcl.2005.07.059

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