1pl0: Difference between revisions

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{{Seed}}
[[Image:1pl0.png|left|200px]]
[[Image:1pl0.png|left|200px]]


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{{STRUCTURE_1pl0|  PDB=1pl0  |  SCENE=  }}  
{{STRUCTURE_1pl0|  PDB=1pl0  |  SCENE=  }}  


===Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC===
===Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC===


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{{ABSTRACT_PUBMED_14966129}}
{{ABSTRACT_PUBMED_14966129}}
==Disease==
Known disease associated with this structure: AICA-ribosiduria due to ATIC deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601731 601731]]


==About this Structure==
==About this Structure==
1PL0 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL0 OCA].  
[[1pl0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL0 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:14966129</ref><references group="xtra"/>
<ref group="xtra">PMID:014966129</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Beardsley, G P.]]
[[Category: Beardsley, G P.]]
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[[Category: Folate-based inhibitor]]
[[Category: Folate-based inhibitor]]
[[Category: Human atic]]
[[Category: Human atic]]
[[Category: Hydrolase]]
[[Category: Imp cyclohydrolase]]
[[Category: Imp cyclohydrolase]]
[[Category: Transferase]]
[[Category: Xanthosine monophosphate]]
[[Category: Xanthosine monophosphate]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:19:06 2009''

Revision as of 11:57, 19 December 2012

File:1pl0.png

Template:STRUCTURE 1pl0

Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC

Template:ABSTRACT PUBMED 14966129

About this Structure

1pl0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200

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