2bop: Difference between revisions

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[[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2bop, resolution 1.700Å" />

'''CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET'''<br />

==Overview==

The dominant transcriptional regulator of the papillomaviruses, E2, binds, to its specific DNA target through a previously unobserved dimeric, antiparallel beta-barrel. The DNA is severely but smoothly bent over the, barrel by the interaction of successive major grooves with a pair of, symmetrically disposed alpha-helices. The specific interface is an, 'interwoven' network of interactions where the identifying base pairs of, the target contact more than one amino-acid side chain and the, discriminating amino acids interact with more than one base pair.

The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.

==About this Structure==

2BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with YB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA].

2BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with <scene name='pdbligand=YB:'>YB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA].

==Reference==

Line 13:

[[Category: Bovine papillomavirus type 1]]

[[Category: Single protein]]

[[Category: Grossman, S.R.]]

[[Category: Grossman, S R.]]

[[Category: Hegde, R.S.]]

[[Category: Hegde, R S.]]

[[Category: Laimins, L.A.]]

[[Category: Laimins, L A.]]

[[Category: Sigler, P.B.]]

[[Category: Sigler, P B.]]

[[Category: YB]]

[[Category: double helix]]

[[Category: protein-dna complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 08:51:~~27 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:00 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2bop, resolution 1.700&Aring;" />
 '''CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET'''<br />
 ==Overview==
-The dominant transcriptional regulator of the papillomaviruses, E2, binds, to its specific DNA target through a previously unobserved dimeric, antiparallel beta-barrel. The DNA is severely but smoothly bent over the, barrel by the interaction of successive major grooves with a pair of, symmetrically disposed alpha-helices. The specific interface is an, 'interwoven' network of interactions where the identifying base pairs of, the target contact more than one amino-acid side chain and the, discriminating amino acids interact with more than one base pair.
+The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.
 ==About this Structure==
-BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with YB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA].
+BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with <scene name='pdbligand=YB:'>YB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bovine papillomavirus type 1]]
 [[Category: Single protein]]
-[[Category: Grossman, S.R.]]
+[[Category: Grossman, S R.]]
-[[Category: Hegde, R.S.]]
+[[Category: Hegde, R S.]]
-[[Category: Laimins, L.A.]]
+[[Category: Laimins, L A.]]
-[[Category: Sigler, P.B.]]
+[[Category: Sigler, P B.]]
 [[Category: YB]]
 [[Category: double helix]]
 [[Category: protein-dna complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:51:27 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:00 2008''