1tqf: Difference between revisions

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{{Seed}}
[[Image:1tqf.png|left|200px]]
[[Image:1tqf.png|left|200px]]


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{{STRUCTURE_1tqf|  PDB=1tqf  |  SCENE=  }}  
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===Crystal structure of human Beta secretase complexed with inhibitor===
===Crystal structure of human Beta secretase complexed with inhibitor===


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{{ABSTRACT_PUBMED_15566281}}
{{ABSTRACT_PUBMED_15566281}}


==About this Structure==
==About this Structure==
1TQF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQF OCA].  
[[1tqf]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQF OCA].  
 
==See Also==
*[[Beta secretase|Beta secretase]]


==Reference==
==Reference==
<ref group="xtra">PMID:15566281</ref><references group="xtra"/>
<ref group="xtra">PMID:015566281</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
Line 32: Line 23:
[[Category: Bace]]
[[Category: Bace]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:27:15 2009''

Revision as of 14:10, 26 July 2012

File:1tqf.png


Drag the structure with the mouse to rotate
1tqf, resolution 1.80Å (default scene)
Ligands: 32P
Gene: BACE1, BACE (Homo sapiens)
Activity: Memapsin 2, with EC number 3.4.23.46
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human Beta secretase complexed with inhibitor

Template:ABSTRACT PUBMED 15566281

About this Structure

1tqf is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T. Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases. J Med Chem. 2004 Dec 2;47(25):6117-9. PMID:15566281 doi:10.1021/jm049388p

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