1hfd: Difference between revisions

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{{Seed}}
[[Image:1hfd.png|left|200px]]
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{{STRUCTURE_1hfd|  PDB=1hfd  |  SCENE=  }}  
{{STRUCTURE_1hfd|  PDB=1hfd  |  SCENE=  }}  
===HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM===
===HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM===
{{ABSTRACT_PUBMED_9753554}}


==Disease==
[[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[http://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_9753554}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.  
(as it appears on PubMed at http://www.pubmed.gov), where 9753554 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9753554}}


==About this Structure==
==About this Structure==
1HFD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFD OCA].  
[[1hfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFD OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:9753554</ref><references group="xtra"/>
<ref group="xtra">PMID:009753554</ref><references group="xtra"/><references/>
[[Category: Complement factor D]]
[[Category: Complement factor D]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 39: Line 29:
[[Category: Self-regulation]]
[[Category: Self-regulation]]
[[Category: Serine protease]]
[[Category: Serine protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:50:28 2009''
Retrieved from "https://proteopedia.org/1hfd"