3c1x: Difference between revisions

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{{Seed}}
[[Image:3c1x.png|left|200px]]
[[Image:3c1x.png|left|200px]]


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{{STRUCTURE_3c1x|  PDB=3c1x  |  SCENE=  }}  
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===Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor===
===Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor===


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{{ABSTRACT_PUBMED_18289854}}
{{ABSTRACT_PUBMED_18289854}}
==Disease==
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]]


==About this Structure==
==About this Structure==
3C1X is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1X OCA].  
[[3c1x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C1X OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:18289854</ref><references group="xtra"/>
<ref group="xtra">PMID:018289854</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
Line 43: Line 28:
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:59:27 2009''

Revision as of 20:10, 7 January 2013

File:3c1x.png

Template:STRUCTURE 3c1x

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor

Template:ABSTRACT PUBMED 18289854

About this Structure

3c1x is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Schroeder GM, Chen XT, Williams DK, Nirschl DS, Cai ZW, Wei D, Tokarski JS, An Y, Sack J, Chen Z, Huynh T, Vaccaro W, Poss M, Wautlet B, Gullo-Brown J, Kellar K, Manne V, Hunt JT, Wong TW, Lombardo LJ, Fargnoli J, Borzilleri RM. Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1945-51. Epub 2008 Feb 7. PMID:18289854 doi:10.1016/j.bmcl.2008.01.121

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