3ela: Difference between revisions

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{{Seed}}
[[Image:3ela.png|left|200px]]
[[Image:3ela.png|left|200px]]


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{{STRUCTURE_3ela|  PDB=3ela  |  SCENE=  }}  
{{STRUCTURE_3ela|  PDB=3ela  |  SCENE=  }}  


===Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor===
===Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor===


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{{ABSTRACT_PUBMED_18640965}}
{{ABSTRACT_PUBMED_18640965}}


==Disease==
==About this Structure==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]]
[[3ela]] is a 3 chain structure of [[Factor VIIa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELA OCA].


==About this Structure==
==See Also==
3ELA is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ELA OCA].
*[[Factor VIIa|Factor VIIa]]


==Reference==
==Reference==
<ref group="xtra">PMID:18640965</ref><references group="xtra"/>
<ref group="xtra">PMID:018640965</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fodje, M.]]
[[Category: Fodje, M.]]
[[Category: Svensson, L A.]]
[[Category: Svensson, L A.]]
[[Category: Allosteric regulation]]
[[Category: Allostery]]
[[Category: Alternative splicing]]
[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Blood coagulation]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Calcium]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disease mutation]]
[[Category: Egf-like domain]]
[[Category: Exosite]]
[[Category: Gamma-carboxyglutamic acid]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydroxylation]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Palmitate]]
[[Category: Pharmaceutical]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:17:26 2009''

Revision as of 16:44, 26 July 2012

File:3ela.png

Template:STRUCTURE 3ela

Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor

Template:ABSTRACT PUBMED 18640965

About this Structure

3ela is a 3 chain structure of Factor VIIa with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Bjelke JR, Olsen OH, Fodje M, Svensson LA, Bang S, Bolt G, Kragelund BB, Persson E. Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity. J Biol Chem. 2008 Sep 19;283(38):25863-70. Epub 2008 Jul 17. PMID:18640965 doi:10.1074/jbc.M800841200

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