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[[Image:1dan.gif|left|100px]]
<applet load="1dan" size="300" color="white" frame="true" align="right" spinBox="true" caption="1DAN " />
<applet load="1dan" size="450" color="white" frame="true" align="right" spinBox="true"  
'''Complex Of Active Site Inhibited Human Blood Coagulation  Factor Viia With Human Recombinant Soluble Tissue Factor'''
caption="1dan" />
''''''<br />
==Overview==
==Overview==
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation.
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation.
==Functional features==
[[Category: Banner DW]]
==Structural features==
[[Category: Chene C]]
==PDB entry information==
[[Category: D'Arcy A]]
'''Author:''' [[D.W.Banner]]  
[[Category: Guha A]]
 
[[Category: Kirchhofer D]]
==Crystal information==
[[Category: Konigsberg WH]]
    <TABLE border=1><tr>
[[Category: Nemerson Y]]
      <td><FONT COLOR=#006600>length a</font></td>
[[Category: Winkler FK]]
      <td><FONT COLOR=#006600>length b</font></td>
      <td><FONT COLOR=#006600>length c</font></td>
      <td><FONT COLOR=#006600>angle alpha</font></td>
      <td><FONT COLOR=#006600>angle beta</font></td>
      <td><FONT COLOR=#006600>angle gamma</font></td>
    </tr> <tr>
        <TD align=right>70.650</td>
        <TD align=right>82.550</td>
        <TD align=right>126.500</td>
        <TD align=right>90.00</td>
        <TD align=right>90.00</td>
        <TD align=right>90.00</td></tr>
    </TABLE>
==Related Structures==
by [http://bioinfo.tg.fh-giessen.de/pdbselect/README homologous] chain: [http://bip.weizmann.ac.il//oca-bin/ocashort?id=1JPS 1JPS], [http://bip.weizmann.ac.il//oca-bin/ocashort?id=1KLI 1KLI], [http://bip.weizmann.ac.il//oca-bin/ocashort?id=1YGC 1YGC], [http://bip.weizmann.ac.il//oca-bin/ocashort?id=1Z6J 1Z6J]


''Page seeded by [http://bip.weizmann.ac.il/oca OCA ] on Thu Oct 25 10:20:37 2007''
''Page seeded by [http://bip.weizmann.ac.il/oca OCA ] on Thu Oct 25 11:09:10 2007''
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