2h8h: Difference between revisions

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{{Seed}}
[[Image:2h8h.png|left|200px]]
[[Image:2h8h.png|left|200px]]


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{{STRUCTURE_2h8h|  PDB=2h8h  |  SCENE=  }}  
{{STRUCTURE_2h8h|  PDB=2h8h  |  SCENE=  }}  


===Src kinase in complex with a quinazoline inhibitor===
===Src kinase in complex with a quinazoline inhibitor===


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{{ABSTRACT_PUBMED_17064066}}
{{ABSTRACT_PUBMED_17064066}}


==About this Structure==
==About this Structure==
2H8H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8H OCA].  
[[2h8h]] is a 1 chain structure of [[Proto-oncogene tyrosine-protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8H OCA].  
 
==See Also==
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:17064066</ref><references group="xtra"/>
<ref group="xtra">PMID:017064066</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Rowsell, S.]]
[[Category: Rowsell, S.]]
[[Category: Src kinase]]
[[Category: Src kinase]]
 
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:49:59 2009''

Revision as of 17:32, 26 July 2012

File:2h8h.png

Template:STRUCTURE 2h8h

Src kinase in complex with a quinazoline inhibitor

Template:ABSTRACT PUBMED 17064066

About this Structure

2h8h is a 1 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hennequin LF, Allen J, Breed J, Curwen J, Fennell M, Green TP, Lambert-van der Brempt C, Morgentin R, Norman RA, Olivier A, Otterbein L, Ple PA, Warin N, Costello G. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem. 2006 Nov 2;49(22):6465-88. PMID:17064066 doi:10.1021/jm060434q

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