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| [[Image:2b7a.png|left|200px]] | | [[Image:2b7a.png|left|200px]] |
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| {{STRUCTURE_2b7a| PDB=2b7a | SCENE= }} | | {{STRUCTURE_2b7a| PDB=2b7a | SCENE= }} |
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| ===The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor=== | | ===The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor=== |
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| {{ABSTRACT_PUBMED_16174768}} | | {{ABSTRACT_PUBMED_16174768}} |
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| ==Disease==
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| Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]]
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| ==About this Structure== | | ==About this Structure== |
| 2B7A is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7A OCA].
| | [[2b7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7A OCA]. |
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| ==Reference== | | ==Reference== |
| <ref group="xtra">PMID:16174768</ref><references group="xtra"/> | | <ref group="xtra">PMID:016174768</ref><references group="xtra"/> |
| [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| [[Category: Transferase]] | | [[Category: Transferase]] |
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| [[Category: Wilks, A F.]] | | [[Category: Wilks, A F.]] |
| [[Category: Kinase]] | | [[Category: Kinase]] |
| | | [[Category: Transferase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:52:11 2009''
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