2dx5: Difference between revisions

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[[Image:2dx5.gif|left|200px]]<br /><applet load="2dx5" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2dx5.gif|left|200px]]<br /><applet load="2dx5" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2dx5, resolution 3.35Å" />

'''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''<br />

==Overview==

ESCRT-II, a complex that sorts ubiquitinated membrane proteins to, lysosomes, localizes to endosomes through interaction between the Vps36, subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a, ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas, its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45, GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site, of Eap45 GLUE, suggesting their independent binding.

ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.

==About this Structure==

2DX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA].

2DX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA].

==Reference==

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[[Category: ubiquitin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 09:49:~~46 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:39 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2dx5.gif|left|200px]]<br /><applet load="2dx5" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2dx5.gif|left|200px]]<br /><applet load="2dx5" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2dx5, resolution 3.35&Aring;" />
 '''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''<br />
 ==Overview==
-ESCRT-II, a complex that sorts ubiquitinated membrane proteins to, lysosomes, localizes to endosomes through interaction between the Vps36, subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a, ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas, its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45, GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site, of Eap45 GLUE, suggesting their independent binding.
+ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.
 ==About this Structure==
-DX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA].
+DX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA].
 ==Reference==
@@ Line 25: / Line 25: @@
 [[Category: ubiquitin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:49:46 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:39 2008''