3ran: Difference between revisions
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{{STRUCTURE_3ran| PDB=3ran | SCENE= }} | {{STRUCTURE_3ran| PDB=3ran | SCENE= }} | ||
===CANINE GDP-RAN Q69L MUTANT=== | ===CANINE GDP-RAN Q69L MUTANT=== | ||
{{ABSTRACT_PUBMED_9878368}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RAN_CANFA RAN_CANFA]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3ran]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAN OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:009878368</ref><references group="xtra"/><references/> | ||
[[Category: Canis lupus familiaris]] | [[Category: Canis lupus familiaris]] | ||
[[Category: Kent, H M.]] | [[Category: Kent, H M.]] | ||
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[[Category: Gtpase]] | [[Category: Gtpase]] | ||
[[Category: Nuclear transport]] | [[Category: Nuclear transport]] | ||
[[Category: Transport protein]] | |||