3c09: Difference between revisions
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===Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR=== | ===Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR=== | ||
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==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
3C09 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens | 3C09 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Homo_sapiens,_mus_musculus Homo sapiens, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C09 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:18394559</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Homo sapiens, mus musculus]] | [[Category: Homo sapiens, mus musculus]] | ||
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[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:20:43 2009'' | ||
Revision as of 09:20, 22 March 2009
Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
Template:ABSTRACT PUBMED 18394559
Disease
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]
About this Structure
3C09 is a 6 chains structure of sequences from Homo sapiens and Homo sapiens, mus musculus. Full crystallographic information is available from OCA.
Reference
- Schmiedel J, Blaukat A, Li S, Knochel T, Ferguson KM. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008 Apr;13(4):365-73. PMID:18394559 doi:10.1016/j.ccr.2008.02.019
Page seeded by OCA on Sun Mar 22 11:20:43 2009
