2es4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /><applet load="2es4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2es4, resolution 1.85Å" /> '''Crystal structure of... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2es4.gif|left|200px]]<br /><applet load="2es4" size=" | [[Image:2es4.gif|left|200px]]<br /><applet load="2es4" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2es4, resolution 1.85Å" /> | caption="2es4, resolution 1.85Å" /> | ||
'''Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase'''<br /> | '''Crystal structure of the Burkholderia glumae lipase-specific foldase in complex with its cognate lipase'''<br /> | ||
==Overview== | ==Overview== | ||
Secretion via the type II secretion pathway in Gram-negative bacteria | Secretion via the type II secretion pathway in Gram-negative bacteria often relies crucially on steric chaperones in the periplasm. Here, we report the crystal structure of the soluble form of a lipase-specific foldase (Lif) from Burkholderia glumae in complex with its cognate lipase. The structure reveals how Lif uses a novel alpha-helical scaffold to embrace lipase, thereby creating an unusually extensive folding platform. | ||
==About this Structure== | ==About this Structure== | ||
2ES4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Burkholderia_glumae Burkholderia glumae] with CA and IOD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] Full crystallographic information is available from [http:// | 2ES4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Burkholderia_glumae Burkholderia glumae] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=IOD:'>IOD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ES4 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Triacylglycerol lipase]] | [[Category: Triacylglycerol lipase]] | ||
[[Category: Gelder, P | [[Category: Gelder, P Van.]] | ||
[[Category: Pauwels, K.]] | [[Category: Pauwels, K.]] | ||
[[Category: Savvides, S | [[Category: Savvides, S N.]] | ||
[[Category: Tommassen, J.]] | [[Category: Tommassen, J.]] | ||
[[Category: Wyns, L.]] | [[Category: Wyns, L.]] | ||
| Line 28: | Line 28: | ||
[[Category: triacylglycerol hydrolase]] | [[Category: triacylglycerol hydrolase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:14:02 2008'' | ||
