2o8m: Difference between revisions

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{{Seed}}
[[Image:2o8m.png|left|200px]]
[[Image:2o8m.png|left|200px]]


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{{STRUCTURE_2o8m|  PDB=2o8m  |  SCENE=  }}  
{{STRUCTURE_2o8m|  PDB=2o8m  |  SCENE=  }}  


===Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease===
===Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease===


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{{ABSTRACT_PUBMED_17444623}}
{{ABSTRACT_PUBMED_17444623}}


==About this Structure==
==About this Structure==
2O8M is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8M OCA].  
[[2o8m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O8M OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:17444623</ref><references group="xtra"/>
<ref group="xtra">PMID:017444623</ref><references group="xtra"/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Hydrolase]]
[[Category: Fischmann, T O.]]
[[Category: Fischmann, T O.]]
[[Category: Madison, V M.]]
[[Category: Madison, V M.]]
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Viral protein]]
[[Category: Viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:22:03 2009''

Revision as of 12:04, 7 January 2013

File:2o8m.png

Template:STRUCTURE 2o8m

Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease

Template:ABSTRACT PUBMED 17444623

About this Structure

2o8m is a 4 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  1. Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl] - 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem. 2007 May 17;50(10):2310-8. Epub 2007 Apr 20. PMID:17444623 doi:10.1021/jm060173k

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