2f44: Difference between revisions

Line 1:

[[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2f44, resolution 2.4Å" />

'''Crystal Structure of the Zinc-bound Shank SAM domain'''<br />

==Overview==

The postsynaptic density (PSD) is a complex assembly of proteins, associated with the postsynaptic membrane that organizes neurotransmitter, receptors, signaling pathways, and regulatory elements within a, cytoskeletal matrix. Here we show that the sterile alpha motif domain of, rat Shank3/ProSAP2, a master scaffolding protein located deep within the, PSD, can form large sheets composed of helical fibers stacked side by, side. Zn2+, which is found in high concentrations in the PSD, binds, tightly to Shank3 and may regulate assembly. Sheets of the Shank protein, could form a platform for the construction of the PSD complex.

The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

==About this Structure==

2F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ZN and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA].

2F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA].

==Reference==

Line 13:

[[Category: Rattus norvegicus]]

[[Category: Single protein]]

[[Category: Baron, M.K.]]

[[Category: Baron, M K.]]

[[Category: Bowie, J.U.]]

[[Category: Bowie, J U.]]

[[Category: Faham, S.]]

[[Category: CL]]

Line 24:

[[Category: zinc]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:30 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2f44, resolution 2.4&Aring;" />
 '''Crystal Structure of the Zinc-bound Shank SAM domain'''<br />
 ==Overview==
-The postsynaptic density (PSD) is a complex assembly of proteins, associated with the postsynaptic membrane that organizes neurotransmitter, receptors, signaling pathways, and regulatory elements within a, cytoskeletal matrix. Here we show that the sterile alpha motif domain of, rat Shank3/ProSAP2, a master scaffolding protein located deep within the, PSD, can form large sheets composed of helical fibers stacked side by, side. Zn2+, which is found in high concentrations in the PSD, binds, tightly to Shank3 and may regulate assembly. Sheets of the Shank protein, could form a platform for the construction of the PSD complex.
+The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
 ==About this Structure==
-F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ZN and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA].
+F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Rattus norvegicus]]
 [[Category: Single protein]]
-[[Category: Baron, M.K.]]
+[[Category: Baron, M K.]]
-[[Category: Bowie, J.U.]]
+[[Category: Bowie, J U.]]
 [[Category: Faham, S.]]
 [[Category: CL]]
@@ Line 24: / Line 24: @@
 [[Category: zinc]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:21:18 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:30 2008''