2ffh: Difference between revisions

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[[Image:2ffh.gif|left|200px]]<br /><applet load="2ffh" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2ffh.gif|left|200px]]<br /><applet load="2ffh" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2ffh, resolution 3.2Å" />

'''THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS'''<br />

==Overview==

The crystal structure of the signal sequence binding subunit of the signal, recognition particle (SRP) from Thermus aquaticus reveals a deep groove, bounded by a flexible loop and lined with side chains of conserved, hydrophobic residues. The groove defines a flexible, hydrophobic, environment that is likely to contribute to the structural plasticity, necessary for SRP to bind signal sequences of different lengths and amino, acid sequence. The structure also reveals a helix-turn-helix motif, containing an arginine-rich alpha helix that is required for binding to, SRP RNA and is implicated in forming the core of an extended RNA binding, surface.

The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.

==About this Structure==

2FFH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with CD and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA].

2FFH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA].

==Reference==

Line 13:

[[Category: Single protein]]

[[Category: Thermus aquaticus]]

[[Category: Freymann, D.M.]]

[[Category: Freymann, D M.]]

[[Category: Keenan, R.J.]]

[[Category: Keenan, R J.]]

[[Category: Stroud, R.M.]]

[[Category: Stroud, R M.]]

[[Category: Walter, P.]]

[[Category: CD]]

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[[Category: srp54]]

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@@ Line 1: / Line 1: @@
-[[Image:2ffh.gif|left|200px]]<br /><applet load="2ffh" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2ffh.gif|left|200px]]<br /><applet load="2ffh" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2ffh, resolution 3.2&Aring;" />
 '''THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS'''<br />
 ==Overview==
-The crystal structure of the signal sequence binding subunit of the signal, recognition particle (SRP) from Thermus aquaticus reveals a deep groove, bounded by a flexible loop and lined with side chains of conserved, hydrophobic residues. The groove defines a flexible, hydrophobic, environment that is likely to contribute to the structural plasticity, necessary for SRP to bind signal sequences of different lengths and amino, acid sequence. The structure also reveals a helix-turn-helix motif, containing an arginine-rich alpha helix that is required for binding to, SRP RNA and is implicated in forming the core of an extended RNA binding, surface.
+The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.
 ==About this Structure==
-FFH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with CD and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA].
+FFH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Thermus aquaticus]]
-[[Category: Freymann, D.M.]]
+[[Category: Freymann, D M.]]
-[[Category: Keenan, R.J.]]
+[[Category: Keenan, R J.]]
-[[Category: Stroud, R.M.]]
+[[Category: Stroud, R M.]]
 [[Category: Walter, P.]]
 [[Category: CD]]
@@ Line 29: / Line 29: @@
 [[Category: srp54]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:32:01 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:53 2008''