1h9d: Difference between revisions

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{{Seed}}
[[Image:1h9d.png|left|200px]]
[[Image:1h9d.png|left|200px]]


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{{STRUCTURE_1h9d|  PDB=1h9d  |  SCENE=  }}  
{{STRUCTURE_1h9d|  PDB=1h9d  |  SCENE=  }}  


===AML1/CBF-BETA/DNA COMPLEX===
===AML1/CBF-BETA/DNA COMPLEX===


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{{ABSTRACT_PUBMED_11276260}}
{{ABSTRACT_PUBMED_11276260}}
==Disease==
Known disease associated with this structure: Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151385 151385]], Platelet disorder, familial, with associated myeloid malignancy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151385 151385]], Rheumatoid arthritis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=151385 151385]], Myeloid leukemia, acute, M4Eo subtype OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=121360 121360]]


==About this Structure==
==About this Structure==
1H9D is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9D OCA].  
[[1h9d]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9D OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:11276260</ref><references group="xtra"/>
<ref group="xtra">PMID:011276260</ref><ref group="xtra">PMID:012217689</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bravo, J.]]
[[Category: Bravo, J.]]
[[Category: Warren, A J.]]
[[Category: Warren, A J.]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:27:11 2009''

Revision as of 16:16, 21 November 2012

File:1h9d.png

Template:STRUCTURE 1h9d

AML1/CBF-BETA/DNA COMPLEX

Template:ABSTRACT PUBMED 11276260

About this Structure

1h9d is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260 doi:https://dx.doi.org/10.1038/86264
  2. Backstrom S, Wolf-Watz M, Grundstrom C, Hard T, Grundstrom T, Sauer UH. The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. J Mol Biol. 2002 Sep 13;322(2):259-72. PMID:12217689

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