2g02: Difference between revisions

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[[Image:2g02.gif|left|200px]]<br /><applet load="2g02" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2g02.gif|left|200px]]<br /><applet load="2g02" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2g02, resolution 2.50Å" />

'''Nisin cyclase'''<br />

==Overview==

Nisin is a posttranslationally modified antimicrobial peptide that is, widely used as a food preservative. It contains five cyclic thioethers of, varying sizes that are installed by a single enzyme, NisC. Reported here, are the in vitro reconstitution of the cyclization process and the x-ray, crystal structure of the NisC enzyme. The structure reveals similarities, in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a, cysteine of a protein substrate.

Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.

==About this Structure==

2G02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA].

2G02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA].

==Reference==

Line 13:

[[Category: Lactococcus lactis subsp. lactis]]

[[Category: Single protein]]

[[Category: Nair, S.K.]]

[[Category: Nair, S K.]]

[[Category: ZN]]

[[Category: alpha barrel]]

[[Category: alpha toroid]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 10:52:~~17 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:50 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2g02.gif|left|200px]]<br /><applet load="2g02" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2g02.gif|left|200px]]<br /><applet load="2g02" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2g02, resolution 2.50&Aring;" />
 '''Nisin cyclase'''<br />
 ==Overview==
-Nisin is a posttranslationally modified antimicrobial peptide that is, widely used as a food preservative. It contains five cyclic thioethers of, varying sizes that are installed by a single enzyme, NisC. Reported here, are the in vitro reconstitution of the cyclization process and the x-ray, crystal structure of the NisC enzyme. The structure reveals similarities, in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a, cysteine of a protein substrate.
+Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes that are installed by a single enzyme, NisC. Reported here are the in vitro reconstitution of the cyclization process and the x-ray crystal structure of the NisC enzyme. The structure reveals similarities in fold and substrate activation with mammalian farnesyl transferases, suggesting that human homologs of NisC posttranslationally modify a cysteine of a protein substrate.
 ==About this Structure==
-G02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA].
+G02 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G02 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Lactococcus lactis subsp. lactis]]
 [[Category: Single protein]]
-[[Category: Nair, S.K.]]
+[[Category: Nair, S K.]]
 [[Category: ZN]]
 [[Category: alpha barrel]]
 [[Category: alpha toroid]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:52:17 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:26:50 2008''