2r4f: Difference between revisions

Revision as of 23:45, 26 December 2010

2r4f is a 4 chain structure of HMG-CoA Reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r

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-{{Seed}}
 [[Image:2r4f.png|left|200px]]
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 {{ABSTRACT_PUBMED_18072721}}
-==Disease==
+==About this Structure==
-Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142910 142910]]
+[[2r4f]] is a 4 chain structure of [[HMG-CoA Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4F OCA].
-==About this Structure==
+==See Also==
-R4F is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4F OCA].
+*[[HMG-CoA Reductase]]
 ==Reference==
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 [[Category: Sterol biosynthesis]]
 [[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:32:17 2009''