2g6w: Difference between revisions
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New page: left|200px<br /><applet load="2g6w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g6w, resolution 2.14Å" /> '''Suicide inhibition o... |
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[[Image:2g6w.gif|left|200px]]<br /><applet load="2g6w" size=" | [[Image:2g6w.gif|left|200px]]<br /><applet load="2g6w" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2g6w, resolution 2.14Å" /> | caption="2g6w, resolution 2.14Å" /> | ||
'''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine'''<br /> | '''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine'''<br /> | ||
==Overview== | ==Overview== | ||
The irreversible inhibition of 8-amino-7-oxononanoate synthase by | The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct. | ||
==About this Structure== | ==About this Structure== | ||
2G6W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with LLF as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] Full crystallographic information is available from [http:// | 2G6W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=LLF:'>LLF</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G6W OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: synthase]] | [[Category: synthase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:28:46 2008'' | ||
