2g7c: Difference between revisions

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[[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2g7c, resolution 2.0Å" />

'''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''<br />

==Overview==

Clostridium difficile TcdA is a large toxin that binds carbohydrates on, intestinal epithelial cells. A 2-A resolution cocrystal structure reveals, two molecules of, alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in, an extended conformation to TcdA. Residues forming key contacts with the, trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the, rational design of novel therapeutics.

Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.

==About this Structure==

2G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA].

2G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Greco, A.]]

[[Category: Ho, J.G.S.]]

[[Category: Ho, J G.S.]]

[[Category: Lin, S.J.]]

[[Category: Lin, S J.]]

[[Category: Ng, K.K.S.]]

[[Category: Ng, K K.S.]]

[[Category: Palcic, M.M.]]

[[Category: Palcic, M M.]]

[[Category: Rupnik, M.]]

[[Category: GOL]]

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[[Category: protein-carbohydrate complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 11:00:~~33 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:28:51 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2g7c.gif|left|200px]]<br /><applet load="2g7c" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2g7c, resolution 2.0&Aring;" />
 '''Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc'''<br />
 ==Overview==
-Clostridium difficile TcdA is a large toxin that binds carbohydrates on, intestinal epithelial cells. A 2-A resolution cocrystal structure reveals, two molecules of, alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in, an extended conformation to TcdA. Residues forming key contacts with the, trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the, rational design of novel therapeutics.
+Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.
 ==About this Structure==
-G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA].
+G7C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7C OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Greco, A.]]
-[[Category: Ho, J.G.S.]]
+[[Category: Ho, J G.S.]]
-[[Category: Lin, S.J.]]
+[[Category: Lin, S J.]]
-[[Category: Ng, K.K.S.]]
+[[Category: Ng, K K.S.]]
-[[Category: Palcic, M.M.]]
+[[Category: Palcic, M M.]]
 [[Category: Rupnik, M.]]
 [[Category: GOL]]
@@ Line 24: / Line 24: @@
 [[Category: protein-carbohydrate complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:00:33 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:28:51 2008''