2gat: Difference between revisions

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[[Image:2gat.gif|left|200px]]<br /><applet load="2gat" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2gat.gif|left|200px]]<br /><applet load="2gat" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2gat" />

'''SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF CHICKEN GATA-1 BOUND TO DNA, NMR, REGULARIZED MEAN STRUCTURE'''<br />

==Overview==

Anisotropy of the molecular magnetic susceptibility gives rise to a small, degree of alignment. The resulting residual dipolar couplings, which can, now be measured with the advent of higher magnetic fields in NMR, contain, information on the orientation of the internuclear vectors relative to the, molecular magnetic susceptibility tensor, thereby providing information on, long range order that is not accessible by any of the solution NMR, parameters currently used in structure determination. Thus, the dipolar, couplings constitute unique and powerful restraints in determining the, structures of magnetically oriented macromolecules in solution. The method, is demonstrated on a complex of the DNA-binding domain of the, transcription factor GATA-1 with a 16 base pair oligodeoxyribonucleotide.

Anisotropy of the molecular magnetic susceptibility gives rise to a small degree of alignment. The resulting residual dipolar couplings, which can now be measured with the advent of higher magnetic fields in NMR, contain information on the orientation of the internuclear vectors relative to the molecular magnetic susceptibility tensor, thereby providing information on long range order that is not accessible by any of the solution NMR parameters currently used in structure determination. Thus, the dipolar couplings constitute unique and powerful restraints in determining the structures of magnetically oriented macromolecules in solution. The method is demonstrated on a complex of the DNA-binding domain of the transcription factor GATA-1 with a 16 base pair oligodeoxyribonucleotide.

==About this Structure==

2GAT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2GAT OCA].

2GAT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAT OCA].

==Reference==

Line 13:

[[Category: Gallus gallus]]

[[Category: Single protein]]

[[Category: Clore, G.M.]]

[[Category: Clore, G M.]]

[[Category: Gronenborn, A.M.]]

[[Category: Gronenborn, A M.]]

[[Category: Omichinski, J.G.]]

[[Category: Omichinski, J G.]]

[[Category: Starich, M.]]

[[Category: Tjandra, N.]]

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[[Category: zinc binding domain]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:56 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2gat.gif|left|200px]]<br /><applet load="2gat" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2gat.gif|left|200px]]<br /><applet load="2gat" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2gat" />
 '''SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF CHICKEN GATA-1 BOUND TO DNA, NMR, REGULARIZED MEAN STRUCTURE'''<br />
 ==Overview==
-Anisotropy of the molecular magnetic susceptibility gives rise to a small, degree of alignment. The resulting residual dipolar couplings, which can, now be measured with the advent of higher magnetic fields in NMR, contain, information on the orientation of the internuclear vectors relative to the, molecular magnetic susceptibility tensor, thereby providing information on, long range order that is not accessible by any of the solution NMR, parameters currently used in structure determination. Thus, the dipolar, couplings constitute unique and powerful restraints in determining the, structures of magnetically oriented macromolecules in solution. The method, is demonstrated on a complex of the DNA-binding domain of the, transcription factor GATA-1 with a 16 base pair oligodeoxyribonucleotide.
+Anisotropy of the molecular magnetic susceptibility gives rise to a small degree of alignment. The resulting residual dipolar couplings, which can now be measured with the advent of higher magnetic fields in NMR, contain information on the orientation of the internuclear vectors relative to the molecular magnetic susceptibility tensor, thereby providing information on long range order that is not accessible by any of the solution NMR parameters currently used in structure determination. Thus, the dipolar couplings constitute unique and powerful restraints in determining the structures of magnetically oriented macromolecules in solution. The method is demonstrated on a complex of the DNA-binding domain of the transcription factor GATA-1 with a 16 base pair oligodeoxyribonucleotide.
 ==About this Structure==
-GAT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GAT OCA].
+GAT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAT OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Gallus gallus]]
 [[Category: Single protein]]
-[[Category: Clore, G.M.]]
+[[Category: Clore, G M.]]
-[[Category: Gronenborn, A.M.]]
+[[Category: Gronenborn, A M.]]
-[[Category: Omichinski, J.G.]]
+[[Category: Omichinski, J G.]]
 [[Category: Starich, M.]]
 [[Category: Tjandra, N.]]
@@ Line 24: / Line 24: @@
 [[Category: zinc binding domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:05:07 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:29:56 2008''