2zm3: Difference between revisions

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{{Seed}}
[[Image:2zm3.png|left|200px]]
[[Image:2zm3.png|left|200px]]


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{{STRUCTURE_2zm3|  PDB=2zm3  |  SCENE=  }}  
{{STRUCTURE_2zm3|  PDB=2zm3  |  SCENE=  }}  


===Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor===
===Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor===


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{{ABSTRACT_PUBMED_18501599}}
{{ABSTRACT_PUBMED_18501599}}


==Disease==
==About this Structure==
Known disease associated with this structure: Insulin-like growth factor I, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147370 147370]]
[[2zm3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZM3 OCA].


==About this Structure==
==See Also==
2ZM3 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZM3 OCA].
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]


==Reference==
==Reference==
<ref group="xtra">PMID:18501599</ref><references group="xtra"/>
<ref group="xtra">PMID:018501599</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
[[Category: Receptor]]
[[Category: Receptor]]
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[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:41:09 2009''

Revision as of 19:50, 20 October 2012

File:2zm3.png

Template:STRUCTURE 2zm3

Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor

Template:ABSTRACT PUBMED 18501599

About this Structure

2zm3 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. Epub 2008 Apr 25. PMID:18501599 doi:10.1016/j.bmcl.2008.04.044

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