3np1: Difference between revisions
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{{STRUCTURE_3np1| PDB=3np1 | SCENE= }} | {{STRUCTURE_3np1| PDB=3np1 | SCENE= }} | ||
===CRYSTAL STRUCTURE OF THE COMPLEX OF NITROPHORIN 1 FROM RHODNIUS PROLIXUS WITH CYANIDE=== | ===CRYSTAL STRUCTURE OF THE COMPLEX OF NITROPHORIN 1 FROM RHODNIUS PROLIXUS WITH CYANIDE=== | ||
{{ABSTRACT_PUBMED_9546222}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NP1_RHOPR NP1_RHOPR]] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing. | |||
==About this Structure== | ==About this Structure== | ||
[[3np1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP1 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:009546222</ref><ref group="xtra">PMID:019140692</ref><references group="xtra"/><references/> | ||
[[Category: Rhodnius prolixus]] | [[Category: Rhodnius prolixus]] | ||
[[Category: Andersen, J F.]] | [[Category: Andersen, J F.]] | ||
| Line 37: | Line 24: | ||
[[Category: Nitric oxide transport]] | [[Category: Nitric oxide transport]] | ||
[[Category: Vasodilator]] | [[Category: Vasodilator]] | ||
Revision as of 12:05, 24 April 2013
CRYSTAL STRUCTURE OF THE COMPLEX OF NITROPHORIN 1 FROM RHODNIUS PROLIXUS WITH CYANIDE
Template:ABSTRACT PUBMED 9546222
Function
[NP1_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing.
About this Structure
3np1 is a 2 chain structure with sequence from Rhodnius prolixus. Full crystallographic information is available from OCA.
Reference
- Weichsel A, Andersen JF, Champagne DE, Walker FA, Montfort WR. Crystal structures of a nitric oxide transport protein from a blood-sucking insect. Nat Struct Biol. 1998 Apr;5(4):304-9. PMID:9546222
- Yang F, Zhang H, Knipp M. A one-residue switch reverses the orientation of a heme b cofactor. Investigations of the ferriheme NO transporters nitrophorin 2 and 7 from the blood-feeding insect Rhodnius prolixus. Biochemistry. 2009 Jan 20;48(2):235-41. PMID:19140692 doi:10.1021/bi8020229
