2i6t: Difference between revisions
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New page: left|200px<br /><applet load="2i6t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i6t, resolution 2.10Å" /> '''Orthorhombic Structu... |
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[[Image:2i6t.jpg|left|200px]]<br /><applet load="2i6t" size=" | [[Image:2i6t.jpg|left|200px]]<br /><applet load="2i6t" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2i6t, resolution 2.10Å" /> | caption="2i6t, resolution 2.10Å" /> | ||
'''Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A'''<br /> | '''Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A'''<br /> | ||
==Overview== | ==Overview== | ||
Recent studies have shown that ubiquitination is an essential factor in | Recent studies have shown that ubiquitination is an essential factor in endosomal sorting and virus assembly. The human TSG101 gene has been demonstrated to belong to a group of genes coding for apparently inactive E2 ubiquitin-conjugating enzymes, which exert regulatory effects on E2 activity in cellular ubiquitination processes. In this study, a novel human cDNA (UEV3) encoding a putative protein of 379 amino acids was isolated from a human placenta library that may represent a partial paralogue of human TSG101. The predicted protein contains an N-terminal domain homologous to the catalytic domain of ubiquitin-conjugating enzymes (Ubc), which is fused to a sequence showing significant homology to members of the lactate dehydrogenase protein family. The UEV3 gene is located on chromosome 11 closely adjacent to TSG101 and LDH-C. Northern blot and UEV3-specific reverse transcription/polymerase chain reaction (RT/PCR) analyses of various colon carcinoma cell lines as well as both normal and tumor samples from colon revealed an expression of the UEV3 cDNA in all tested samples. | ||
==About this Structure== | ==About this Structure== | ||
2I6T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 2I6T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6T OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C H.]] | ||
[[Category: Avvakumov, G | [[Category: Avvakumov, G V.]] | ||
[[Category: Bochkarev, A.]] | [[Category: Bochkarev, A.]] | ||
[[Category: Butler-Cole, C.]] | [[Category: Butler-Cole, C.]] | ||
[[Category: Dhe-Paganon, S.]] | [[Category: Dhe-Paganon, S.]] | ||
[[Category: Edwards, A | [[Category: Edwards, A M.]] | ||
[[Category: Jr., P | [[Category: Jr., P J.Finerty.]] | ||
[[Category: Newman, E | [[Category: Newman, E M.]] | ||
[[Category: Sundstrom, M.]] | [[Category: Sundstrom, M.]] | ||
[[Category: Tempel, W.]] | [[Category: Tempel, W.]] | ||
[[Category: Walker, J | [[Category: Walker, J R.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: Xue, S.]] | [[Category: Xue, S.]] | ||
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[[Category: ubiquitin-protein ligase]] | [[Category: ubiquitin-protein ligase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:49:41 2008'' | ||
