1ff1: Difference between revisions

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{{Seed}}
[[Image:1ff1.png|left|200px]]
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{{STRUCTURE_1ff1|  PDB=1ff1  |  SCENE=  }}  
{{STRUCTURE_1ff1|  PDB=1ff1  |  SCENE=  }}  
===STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFL===
===STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFL===
{{ABSTRACT_PUBMED_11062555}}


==Disease==
[[http://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN]] Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_11062555}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN]] Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.<ref>PMID:18362181</ref><ref>PMID:19458185</ref><ref>PMID:22648170</ref><ref>PMID:16903783</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 11062555 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11062555}}


==About this Structure==
==About this Structure==
1FF1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FF1 OCA].  
[[1ff1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FF1 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:11062555</ref><references group="xtra"/>
<ref group="xtra">PMID:011062555</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Beer, T De.]]
[[Category: Beer, T De.]]
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[[Category: Npf]]
[[Category: Npf]]
[[Category: Signaling domain]]
[[Category: Signaling domain]]
 
[[Category: Signaling protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:00:06 2009''
Retrieved from "https://proteopedia.org/1ff1"