Sandbox10: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
Myosin II is found in the myofibers of skeletal, smooth, and cardiac muscle tissue where the protein forms the thick filaments. The myosin of the thick filaments has the ability to bind the thin filaments, composed of actin. The myosin head then rotates and pulls the two filaments past one another providing the basis for muscle contraction. | Myosin II is found in the myofibers of skeletal, smooth, and cardiac muscle tissue where the protein forms the thick filaments. The myosin of the thick filaments has the ability to bind the thin filaments, composed of actin. The myosin head then rotates and pulls the two filaments past one another providing the basis for muscle contraction. | ||
The portion of the protein that is shown is the motor domain of the heavy chain. This protein is largely composed of <scene name='Sandbox10/Helix/1'>alpha-helices</scene> connected by . | The portion of the protein that is shown is the motor domain of the heavy chain. This protein is largely composed of <scene name='Sandbox10/Helix/1'>alpha-helices</scene> connected by randomly oriented chains. There are also several areas of <scene name='Sandbox10/Betasheets/1'>beta-sheets</scene>, both parallel and anti-parallel. | ||
This view shows the <scene name='Sandbox10/Newscene/2'>active sites</scene> of the protein with the ATP analog ADP-Metavanadate bound to one active site and the allosteric inhibitor pentabromopseudilin. | This view shows the <scene name='Sandbox10/Newscene/2'>active sites</scene> of the protein with the ATP analog ADP-Metavanadate bound to one active site and the allosteric inhibitor pentabromopseudilin. | ||
Myosin contains many <scene name='Sandbox10/Polar/1'> | Myosin contains many <scene name='Sandbox10/Polar/1'>polar</scene> side chains on the surface of the protein, but there are also a large number of nonpolar molecules on the surface. The following <scene name='Sandbox10/Hydrophobic/1'>scene</scene> shows a contrast between hydrophobic (gray) and hydrophilic molecules on the surface of the protein. | ||
Thanks to Fedorov, R., Boehl, M., Tsiavaliaris, G., Hartmann, F.K., Baruch, P., Brenner, B., Martin, R., Knoelker, H.J., Gutzeit, H.O., Manstein, D.J. for their work in resolving the structure of this protein. | Thanks to Fedorov, R., Boehl, M., Tsiavaliaris, G., Hartmann, F.K., Baruch, P., Brenner, B., Martin, R., Knoelker, H.J., Gutzeit, H.O., Manstein, D.J. for their work in resolving the structure of this protein. | ||
{{STRUCTURE_2jhr | PDB=2jhr | SCENE= }} | {{STRUCTURE_2jhr | PDB=2jhr | SCENE= }} | ||
