Sandbox22: Difference between revisions
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==Glucokinase== | ==Glucokinase== | ||
Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus. | Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus. | ||
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===Reference=== | ===Reference=== | ||
http://www.proteopedia.org/wiki/index.php/1v4s | http://www.proteopedia.org/wiki/index.php/1v4s | ||
--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran | |||
and Matt Joseph Rozin (because he's so nice to us....) | |||
