Sandbox21: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
This is the protein Trypsin,it has <scene name='Sandbox21/Trypsin_alpha_helix/1'>alpha helices</scene> (shown in red) and also <scene name='Sandbox21/Trypsin_beta_sheets/1'>beta sheets</scene> (shown in blue), now the <scene name='Sandbox21/Trypsin_hydrophobic/1'>hydrophobic</scene> parts of Trypsin are on both the surface and inside. | This is the protein Trypsin,it has <scene name='Sandbox21/Trypsin_alpha_helix/1'>alpha helices</scene> (shown in red) and also <scene name='Sandbox21/Trypsin_beta_sheets/1'>beta sheets</scene> (shown in blue), now the <scene name='Sandbox21/Trypsin_hydrophobic/1'>hydrophobic</scene> parts of Trypsin are on both the surface and inside. | ||
Trypsin is an enzyme that breaks down protein, that is produced in the pancreas and then secreted in to the small intestines. It is a homolog of chymotrypsin and it works by cleveing at the paptide bond after residues with long, positively charged side chains. An aspartate residue which | Trypsin is an enzyme that breaks down protein, that is produced in the pancreas and then secreted in to the small intestines. It is a homolog of chymotrypsin and it works by cleveing at the paptide bond after residues with long, positively charged side chains. An aspartate residue which attracts and stabilizes a positively charged arginine or lysine residue in the substrate. The disease of cystic fibrosis is the result of deficiency in transport of trypsin and other digestive enzymes from the pancreas. | ||
{{STRUCTURE_2cmy | PDB=2cmy | SCENE= }} | {{STRUCTURE_2cmy | PDB=2cmy | SCENE= }} | ||
Reference- | Reference- | ||
Berg, Tymoczko, Stryer, Biochemistry 6th ed. W.H. Freeman and CO. | |||
