Sandbox315: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Macrophage Elastase== | ==Macrophage Elastase== | ||
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. | Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has one <scene name='Sandbox315/Beta_sheet/1'>Beta Sheet</scene> highlighted in purple. | ||
<scene name='Sandbox315/Beta_sheet/1'>Beta Sheet</scene> | <scene name='Sandbox315/Beta_sheet/1'>Beta Sheet</scene> | ||
Revision as of 16:45, 4 March 2009
This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani
Macrophage Elastase
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a hydrophobic active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has one Beta Sheet highlighted in purple.
Reference[1]
| |||||||||||||
| 1jk3, resolution 1.09Å (default scene) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | BAT, CA, ZN | ||||||||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||||||||
| |||||||||||||
| |||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
