Sandbox315

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani

Macrophage Elastase

Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a hydrophobic active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two beta sheets shown in purple.

Reference[1]

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1jk3' size='350' frame='false' scene=
1jk3, resolution 1.09Å (default scene)
Ligands:	BAT, CA, ZN
Activity:	Macrophage elastase, with EC number 3.4.24.65
Structural annotation: Resources: CATH : 1Jk3A00 InterPro : Ipr006025, Ipr000585, Ipr001818, Ipr006026, Ipr002477 Pfam : PF00413 SCOP : d1jk3a_ UniProt : P39900
Functional annotation: Cellular component: proteinaceous extracellular matrix Biological process: metabolic process cell motility proteolysis Molecular function: peptidase activity zinc ion binding catalytic activity hydrolase activity calcium ion binding metallopeptidase activity metal ion binding macrophage elastase activity metalloendopeptidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml