Conservation, Evolutionary: Difference between revisions

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→Caveat: improving Caveat
Eric Martz (talk | contribs)
→Caveat: improving Caveat
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Therefore, residues with, for example, conservation level 9 (maximal conservation) in each of the three sequence-different chains do not have exactly the same levels of conservation.
Therefore, residues with, for example, conservation level 9 (maximal conservation) in each of the three sequence-different chains do not have exactly the same levels of conservation.
{| class="wikitable"
|-
! Chain
! Number of sequences in MSA
! APD
|-
| A
| 144
| 1.72
|-
| B
| 75
| 1.49
|-
| C
| colspan="2" | Length below minimum for ConSurf
|-
| G
| 201
| 1.35
|}


In Proteopedia's ''Evolutionary Conservation'' scenes, we have chosen to color all the chains in the molecule at once. This gives a potentially useful overview, but can be misleading unless one realizes that a given conservation color, in two sequence-different chains, does not mean exactly the same level of conservation. In contrast to Proteopedia's ''Evolutionary Conservation'' scenes,  ConSurfDB and ConSurf Server apply conservation level colors to only one chain sequence at a time, thereby avoiding this possible confusion.
In Proteopedia's ''Evolutionary Conservation'' scenes, we have chosen to color all the chains in the molecule at once. This gives a potentially useful overview, but can be misleading unless one realizes that a given conservation color, in two sequence-different chains, does not mean exactly the same level of conservation. In contrast to Proteopedia's ''Evolutionary Conservation'' scenes,  ConSurfDB and ConSurf Server apply conservation level colors to only one chain sequence at a time, thereby avoiding this possible confusion.