2o0t: Difference between revisions
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New page: left|200px<br /><applet load="2o0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o0t, resolution 2.33Å" /> '''The three dimensiona... |
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[[Image:2o0t.gif|left|200px]]<br /><applet load="2o0t" size=" | [[Image:2o0t.gif|left|200px]]<br /><applet load="2o0t" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2o0t, resolution 2.33Å" /> | caption="2o0t, resolution 2.33Å" /> | ||
'''The three dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation'''<br /> | '''The three dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation'''<br /> | ||
==Overview== | ==Overview== | ||
Diaminopimelate decarboxylase from Mycobacterium tuberculosis (LysA, DAPDC, Rv1293) has been cloned and heterologously expressed in Escherichia | Diaminopimelate decarboxylase from Mycobacterium tuberculosis (LysA, DAPDC, Rv1293) has been cloned and heterologously expressed in Escherichia coli, purified using standard chromatographic techniques and crystallized. Preliminary diffraction data analysis suggests the presence of a homotetramer in the asymmetric unit. | ||
==About this Structure== | ==About this Structure== | ||
2O0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20] Full crystallographic information is available from [http:// | 2O0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O0T OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kefala, G.]] | [[Category: Kefala, G.]] | ||
[[Category: TBSGC, TB | [[Category: TBSGC, TB Structural Genomics Consortium.]] | ||
[[Category: Weiss, M | [[Category: Weiss, M S.]] | ||
[[Category: Weyand, S.]] | [[Category: Weyand, S.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: tbsgc]] | [[Category: tbsgc]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:13:13 2008'' | ||
