User:Nathan Roy: Difference between revisions

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When MA is not bound to PI(4,5)P2 (Figure 1) <applet load='2h3f' size='300' frame='true' align='right' caption=' FIGURE 1. MA unbound to PI(4,5)P2' />, notice the alignment of helix 1, and more precisely, the orientation of Leu 8 and Glu 12. '''INSERT SCENE SHOWING RESIDUES''' In this PI(4,5)P2 unbound structure, the myristyl group is sequestered in the pocket of helix 1 created by Leu 8 and Glu 12. Upon binding of PI(4,5)P2 to the hydrophobic groove created by helix 2, a type 2 beta turn, and helix 5, a slight conformational switch occurs in helix 1 (Figure 2), <applet load='2h3z' size='300' frame='true' align='~~right~~' caption='FIGURE 2. MA bound to PI(4,5)P2' /> causing a change in the alignment of Leu 8 and Glu 12, ejecting the myristyl group from it's sequestered state. '''INSERT SCENE SHOWING RESIDUES'''

When MA is not bound to PI(4,5)P2 (Figure 1) <applet load='2h3f' size='300' frame='true' align='right' caption=' FIGURE 1. MA unbound to PI(4,5)P2' />, notice the alignment of helix 1, and more precisely, the orientation of Leu 8 and Glu 12. '''INSERT SCENE SHOWING RESIDUES''' In this PI(4,5)P2 unbound structure, the myristyl group is sequestered in the pocket of helix 1 created by Leu 8 and Glu 12. Upon binding of PI(4,5)P2 to the hydrophobic groove created by helix 2, a type 2 beta turn, and helix 5, a slight conformational switch occurs in helix 1 (Figure 2), <applet load='2h3z' size='300' frame='true' align='left' caption='FIGURE 2. MA bound to PI(4,5)P2' /> causing a change in the alignment of Leu 8 and Glu 12, ejecting the myristyl group from it's sequestered state. '''INSERT SCENE SHOWING RESIDUES'''

User:Nathan Roy: Difference between revisions

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Revision as of 19:04, 19 April 2009 view source Nathan Roy (talk \| contribs) 76 edits No edit summary ← Older edit		Revision as of 19:06, 19 April 2009 view source Nathan Roy (talk \| contribs) 76 edits No edit summary Newer edit →
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	When MA is not bound to PI(4,5)P2 (Figure 1) <applet load='2h3f' size='300' frame='true' align='right' caption=' FIGURE 1. MA unbound to PI(4,5)P2' />, notice the alignment of helix 1, and more precisely, the orientation of Leu 8 and Glu 12. '''INSERT SCENE SHOWING RESIDUES''' In this PI(4,5)P2 unbound structure, the myristyl group is sequestered in the pocket of helix 1 created by Leu 8 and Glu 12. Upon binding of PI(4,5)P2 to the hydrophobic groove created by helix 2, a type 2 beta turn, and helix 5, a slight conformational switch occurs in helix 1 (Figure 2), <applet load='2h3z' size='300' frame='true' align='~~right~~' caption='FIGURE 2. MA bound to PI(4,5)P2' /> causing a change in the alignment of Leu 8 and Glu 12, ejecting the myristyl group from it's sequestered state. '''INSERT SCENE SHOWING RESIDUES'''		When MA is not bound to PI(4,5)P2 (Figure 1) <applet load='2h3f' size='300' frame='true' align='right' caption=' FIGURE 1. MA unbound to PI(4,5)P2' />, notice the alignment of helix 1, and more precisely, the orientation of Leu 8 and Glu 12. '''INSERT SCENE SHOWING RESIDUES''' In this PI(4,5)P2 unbound structure, the myristyl group is sequestered in the pocket of helix 1 created by Leu 8 and Glu 12. Upon binding of PI(4,5)P2 to the hydrophobic groove created by helix 2, a type 2 beta turn, and helix 5, a slight conformational switch occurs in helix 1 (Figure 2), <applet load='2h3z' size='300' frame='true' align='left' caption='FIGURE 2. MA bound to PI(4,5)P2' /> causing a change in the alignment of Leu 8 and Glu 12, ejecting the myristyl group from it's sequestered state. '''INSERT SCENE SHOWING RESIDUES'''