Cation-pi interactions: Difference between revisions
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New page: The flat face of an aromatic ring has a partial negative charge due to the pi orbitals. Cationic sidechains (Asp, Glu) or sometimes ligands (including metal ions) often align themselves ce... |
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*[[2wea]]: the longest single chain (323 residues) with no energetically significant cation-pi interactions. | *[[2wea]]: the longest single chain (323 residues) with no energetically significant cation-pi interactions. | ||
Interesting examples noted by | Interesting examples noted by [[User:Eric_Martz]]: | ||
*[[1axi]] (human growth hormone): Chain B contains an unusual string of three aromatic sidechains separated by, and capped at the ends with, 4 cationic sidechains. (Using "c" for cation and "p" for pi, the chain is "cpcpcpc".) Only the one of these six interactions is deemed energetically insignificant by CaPTURE (Lys at one end). See image [http://www.umass.edu/microbio/chime/pe_beta/pe/protexpl/cp-1axi.gif here]. | *[[1axi]] (human growth hormone): Chain B contains an unusual string of three aromatic sidechains separated by, and capped at the ends with, 4 cationic sidechains. (Using "c" for cation and "p" for pi, the chain is "cpcpcpc".) Only the one of these six interactions is deemed energetically insignificant by CaPTURE (Lys at one end). See image [http://www.umass.edu/microbio/chime/pe_beta/pe/protexpl/cp-1axi.gif here]. | ||
