Cation-pi interactions: Difference between revisions
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*[[2wea]]: the longest single chain (323 residues) with no energetically significant cation-pi interactions. | *[[2wea]]: the longest single chain (323 residues) with no energetically significant cation-pi interactions. | ||
Interesting examples noted by [[User:Eric_Martz]]: | Interesting examples noted by [[User:Eric_Martz| Eric Martz]]: | ||
*[[1axi]] (human growth hormone): Chain B contains an unusual string of three aromatic sidechains separated by, and capped at the ends with, 4 cationic sidechains. (Using "c" for cation and "p" for pi, the chain is "cpcpcpc".) Only the one of these six interactions is deemed energetically insignificant by CaPTURE (Lys at one end). See image [http://www.umass.edu/microbio/chime/pe_beta/pe/protexpl/cp-1axi.gif here]. | *[[1axi]] (human growth hormone): Chain B contains an unusual string of three aromatic sidechains separated by, and capped at the ends with, 4 cationic sidechains. (Using "c" for cation and "p" for pi, the chain is "cpcpcpc".) Only the one of these six interactions is deemed energetically insignificant by CaPTURE (Lys at one end). See image [http://www.umass.edu/microbio/chime/pe_beta/pe/protexpl/cp-1axi.gif here]. | ||
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*[[1dlh]] (peptide bound to class II histocompatibility protein): There are no cation-pi interactions for the 13-residue peptide, despite its containing three lysines and one tyrosine. A number of nearby sidechains that potentially could interact appear to be blocked by other noncovalent bonding interactions, and the peptide lysine sidechains are generally pointing away from the protein. | *[[1dlh]] (peptide bound to class II histocompatibility protein): There are no cation-pi interactions for the 13-residue peptide, despite its containing three lysines and one tyrosine. A number of nearby sidechains that potentially could interact appear to be blocked by other noncovalent bonding interactions, and the peptide lysine sidechains are generally pointing away from the protein. | ||
== | ==Literature References== | ||
<references/> | <references/> | ||
==Additional Literature and Resources== | |||
<ref group="xtra">PMID: 8539615</ref> | |||
<ref group="xtra">PMID: 15225993</ref> | |||
<ref group="xtra">PMID: 18759391</ref> | |||
<ref group="xtra">PMID: 15726638</ref> | |||
<ref group="xtra">PMID: 12162741</ref> | |||
<ref group="xtra">PMID: 17154537</ref> | |||
<ref group="xtra">PMID: 15726638</ref> | |||
<ref group="xtra">PMID: 17513416</ref> | |||
<references group="xtra"/> | |||
==Content Attribution== | ==Content Attribution== | ||
