NS5B: Difference between revisions
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<scene name='NS5B/Native_ns5b/2'>3 active site aspartates</scene> | <scene name='NS5B/Native_ns5b/2'>3 active site aspartates</scene> | ||
<scene name='NS5B/Native_ns5b/3'>Domains</scene> | <scene name='NS5B/Native_ns5b/3'>Domains</scene> | ||
<applet load='2HAI_DNA5.pdb' size='600' frame='true' align='right' caption='PDB IDs 2HAI (protein) 1RTD (DNA)' />NS5B with B form DNA from HIV Reverse Transcriptase co-crystal model. DNA was modeled in by alignment of palms domain. A beta hairpin in the thumb domain has been moved to accommodate DNA, the hairpin is modeled into the minor groove, a possible binding site. Catalytic Mg2+ ions are modeled in green, these would be coordinated by the three aspartic acid carboxylates, (D220, D318 and D319). | <applet load='2HAI_DNA5.pdb' size='600' frame='true' align='right' caption='PDB IDs 2HAI (protein) 1RTD (DNA)' />NS5B with B form DNA from HIV Reverse Transcriptase co-crystal model. DNA was modeled in by alignment of palms domain. A beta hairpin in the thumb domain has been moved to accommodate DNA, the hairpin is modeled into the minor groove, a possible binding site. Catalytic Mg2+ ions are modeled in green, these would be coordinated by the three aspartic acid carboxylates, (D220, D318 and D319). | ||
