NS5B: Difference between revisions
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Figure 4 is a depiction of each of the protein products of NS5B genomic translation. The proteins coded for by the hepatitis C virus (HCV) genome all associate with the ER membrane. The proteins are translated as one large poly-protein that is enzymatically cleaved by both host and viral proteases. Of the several proteins that are coded for by HCV, three have been identified as relevant drug targets, these are the NS3 protease and helicase domains and the NS5B RNA dependent RNA polymerase. Currently the therapy for HCV is interferon therapy often in combination with ribavirin. This therapy however is inadequate as it is not effective in each genotype of HCV, it is not well tolerated, and expensive. For these reasons many academic and industrial laboratories have been working on developing novel inhibitors of NS5B. | |||
[[Image:PolyProtein.jpg]] | [[Image:PolyProtein.jpg]] | ||
http://www.nature.com/nrmicro/journal/v5/n6/fig_tab/nrmicro1645_F4.html | http://www.nature.com/nrmicro/journal/v5/n6/fig_tab/nrmicro1645_F4.html | ||
