NMR Ensembles of Models: Difference between revisions
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The alignment can affect your perception of the variation between models. For example, calmodulin contains two [[EF-hands]] connected by a flexible linker. When calmodulin is not bound to a cognate peptide, the two EF-hands can move relative to each other, flexing the linker. In [[1cfc]], the N-terminal EF-hands are aligned, but the C-terminal EF-hands are in different orientations. Alternatively, had the C-terminal EF-hands been aligned, then the N-terminal EF-hands would be in variable orientations. And less plausibly, had a short center segment of the flexible linker been aligned, both ends would be in variable orientations. | The alignment can affect your perception of the variation between models. For example, calmodulin contains two [[EF-hands]] connected by a flexible linker. When calmodulin is not bound to a cognate peptide, the two EF-hands can move relative to each other, flexing the linker. In [[1cfc]], the N-terminal EF-hands are aligned, but the C-terminal EF-hands are in different orientations. Alternatively, had the C-terminal EF-hands been aligned, then the N-terminal EF-hands would be in variable orientations. And less plausibly, had a short center segment of the flexible linker been aligned, both ends would be in variable orientations. | ||
Another example of two folded domains (zinc fingers) connected by a flexible linker is [[1zu1]]. Again, only one domain can be aligned, and which one is arbitrary. | |||
==References and Websites== | ==References and Websites== | ||
<references /> | <references /> | ||
