1dan: Difference between revisions
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==Overview== | ==Overview== | ||
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for | Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for ... [[http://ispc.weizmann.ac.il/pmbin/getpm?8598903 (full description)]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: FUC]] | [[Category: FUC]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 11:49:02 2007'' | ||
