Factor IX: Difference between revisions
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== Carboxyglutamate: Post-translational carboxylation of glutamate residues (Glu) into gammacarboxy glutamate (Gla) == | == ''γ''-Carboxyglutamate: Post-translational carboxylation of glutamate residues (Glu) into gammacarboxy glutamate (Gla) == | ||
[[Image:Research_02_big4.JPG|frame|right|http://www.molecular-haemostasis.de/grfx/pix/]] | [[Image:Research_02_big4.JPG|frame|right|http://www.molecular-haemostasis.de/grfx/pix/]] | ||
The post-translational modification of the glutamic acid residues of the FIX polypeptide is carried out by vitamin K-dependent -glutamyl carboxylase (1). Vitamin K-dependent carboxylase is a membrane associated protein in the endoplasmic reticulum. It converts a multiple of glutamic acid residues which are located within 40 residues of a propeptide-containing sequence into - ''γ''-carboxyglutamate (2). | The post-translational modification of the glutamic acid residues of the FIX polypeptide is carried out by vitamin K-dependent ''γ''-glutamyl carboxylase (1). Vitamin K-dependent carboxylase is a membrane associated protein in the endoplasmic reticulum. It converts a multiple of glutamic acid residues which are located within 40 residues of a propeptide-containing sequence into - ''γ''-carboxyglutamate (2). | ||
