Factor IX: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 124: | Line 124: | ||
== γ-Carboxyglutamic Acid (Gla) Domain == | == γ-Carboxyglutamic Acid (Gla) Domain == | ||
<applet load='1lbg' size=' | <applet load='1lbg' size='380' frame='true' align='left' scene='Factor_IX/Gladomain/1' /> | ||
The Gla domain is situated at the N-terminus of coagulation factor IX, and is evolutionary conserved in other vitamin K dependent proteins such as factor VII, X, and prothrombin. A Gla domain is made up of 10-13 of γ-carboxyglutamic acid residues and requires both Ca2+ and Mg2+ ions for membrane association and stabilization of its active three dimensional conformation (2-4). | The Gla domain is situated at the N-terminus of coagulation factor IX, and is evolutionary conserved in other vitamin K dependent proteins such as factor VII, X, and prothrombin. A Gla domain is made up of 10-13 of γ-carboxyglutamic acid residues and requires both Ca2+ and Mg2+ ions for membrane association and stabilization of its active three dimensional conformation (2-4). | ||
