2ran: Difference between revisions

Line 1:

[[Image:2ran.jpg|left|200px]]<br /><applet load="2ran" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2ran.jpg|left|200px]]<br /><applet load="2ran" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2ran, resolution 1.89Å" />

'''RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES'''<br />

==Overview==

Annexins are a family of calcium- and phospholipid-binding proteins, implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of, rat annexin V was solved to 1.9 angstrom resolution by multiple, isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the, third domain induced a large relocation of the calcium-binding loop, regions, exposing the single tryptophan residue to the solvent. These, alterations in annexin V suggest a role for domain 3 in calcium-triggered, interaction with phospholipid membranes.

Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V was solved to 1.9 angstrom resolution by multiple isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the third domain induced a large relocation of the calcium-binding loop regions, exposing the single tryptophan residue to the solvent. These alterations in annexin V suggest a role for domain 3 in calcium-triggered interaction with phospholipid membranes.

==About this Structure==

2RAN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2RAN OCA].

2RAN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAN OCA].

==Reference==

Line 13:

[[Category: Rattus norvegicus]]

[[Category: Single protein]]

[[Category: Concha, N.O.]]

[[Category: Concha, N O.]]

[[Category: Dedman, J.R.]]

[[Category: Dedman, J R.]]

[[Category: Head, J.F.]]

[[Category: Head, J F.]]

[[Category: Kaetzel, M.A.]]

[[Category: Kaetzel, M A.]]

[[Category: Seaton, B.A.]]

[[Category: Seaton, B A.]]

[[Category: CA]]

[[Category: SO4]]

[[Category: calcium/phospholipid-binding protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 13:57:~~05 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:00 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2ran.jpg|left|200px]]<br /><applet load="2ran" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2ran.jpg|left|200px]]<br /><applet load="2ran" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2ran, resolution 1.89&Aring;" />
 '''RAT ANNEXIN V CRYSTAL STRUCTURE: CA2+-INDUCED CONFORMATIONAL CHANGES'''<br />
 ==Overview==
-Annexins are a family of calcium- and phospholipid-binding proteins, implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of, rat annexin V was solved to 1.9 angstrom resolution by multiple, isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the, third domain induced a large relocation of the calcium-binding loop, regions, exposing the single tryptophan residue to the solvent. These, alterations in annexin V suggest a role for domain 3 in calcium-triggered, interaction with phospholipid membranes.
+Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V was solved to 1.9 angstrom resolution by multiple isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the third domain induced a large relocation of the calcium-binding loop regions, exposing the single tryptophan residue to the solvent. These alterations in annexin V suggest a role for domain 3 in calcium-triggered interaction with phospholipid membranes.
 ==About this Structure==
-RAN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RAN OCA].
+RAN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAN OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Rattus norvegicus]]
 [[Category: Single protein]]
-[[Category: Concha, N.O.]]
+[[Category: Concha, N O.]]
-[[Category: Dedman, J.R.]]
+[[Category: Dedman, J R.]]
-[[Category: Head, J.F.]]
+[[Category: Head, J F.]]
-[[Category: Kaetzel, M.A.]]
+[[Category: Kaetzel, M A.]]
-[[Category: Seaton, B.A.]]
+[[Category: Seaton, B A.]]
 [[Category: CA]]
 [[Category: SO4]]
 [[Category: calcium/phospholipid-binding protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:57:05 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:00 2008''