Sandbox 70

Please do NOT make changes to this Sandbox until after April 30, 2009. Sandboxes 60-80 are reserved until then for use by students of East High, Buffalo NY. About Topoisomerases You may wonder do DNA get tangle or do they get stressed?Well the answer is yes but there a protein that relaxes and untangles DNA,it called Topoisomerases. Topoisomerases is a protein that untangle and relax DNA. spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1a36' size='350' frame='false' scene= 1a36, resolution 2.80Å (default scene) Activity: DNA topoisomerase, with EC number 5.99.1.2 Structural annotation: Resources: CATH : 1A36A03, 1A36A02, 1A36A01, 1A36A04 InterPro : Ipr011010, Ipr009054, Ipr013500, Ipr013499, Ipr001631, Ipr013030, Ipr008336, Ipr014727, Ipr014711 Pfam : PF02919, PF01028 SCOP : d1a36a2, d1a36a1, d1a36a3 UniProt : P11387 Functional annotation: Cellular component: nucleolus perikaryon chromosome nucleoplasm cytoplasm nucleus Biological process: DNA unwinding during replication response to drug embryonic cleavage phosphorylation DNA topological change programmed cell death DNA replication Molecular function: DNA topoisomerase activity DNA topoisomerase (ATP-hydrolyzing) activity DNA binding chromatin binding protein binding isomerase activity DNA topoisomerase type I activity Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB Resources: FirstGlance, OCA, RCSB, PDBsum Coordinates: save as pdb, mmCIF, xml