Sandbox 5: Difference between revisions
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The NOS reaction requires five redox-active cofactors. | The NOS reaction requires five redox-active cofactors. | ||
The reaction of NOS: | |||
As previously described NOS is an enzyme split in to different domains; the N-terminal oxygenase domain and the C-terminal reductase domain. | |||
The oxygenase domain is where the production of NO takes place, whereas the reductase domain provides the electrons necessary to drive the reaction in the oxygenase domain. | |||
The reaction is: | |||
INDSÆT FIGUR | |||
The amino acid L-Arginine is turned in to L-Citrulline and NO. The reaction is driven by the oxidation of NADPH to NADP+, which in total yields 5 electrons for the reaction. | |||
The reaction above therefore takes both the oxygenase and the reductase domain into account. | |||
== Structure == | == Structure == | ||
