2tss: Difference between revisions

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[[Image:2tss.gif|left|200px]]<br /><applet load="2tss" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:2tss.gif|left|200px]]<br /><applet load="2tss" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2tss, resolution 2.05Å" />

'''TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM'''<br />

==Overview==

The structure of toxic shock syndrome toxin-1 (TSST-1), the causative, agent in toxic shock syndrome, has been determined in three crystal forms., The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between, two symmetry-related molecules. Although not required for biological, activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very, low concentrations. In addition, the structure of the tetramutant TSST-1H, [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify, endotoxin shock, has been determined and refined in a fourth crystal form, (R-factor = 0.173 to 1.9 A resolution).

The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).

==About this Structure==

2TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure ~~superseeds~~ the now removed PDB entry 1TSS. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2TSS OCA].

2TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure supersedes the now removed PDB entry 1TSS. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSS OCA].

==Reference==

Line 13:

[[Category: Single protein]]

[[Category: Staphylococcus aureus]]

[[Category: Cook, W.J.]]

[[Category: Cook, W J.]]

[[Category: Dinges, M.M.]]

[[Category: Dinges, M M.]]

[[Category: Earhart, C.A.]]

[[Category: Earhart, C A.]]

[[Category: Mitchell, D.T.]]

[[Category: Mitchell, D T.]]

[[Category: Ohlendorf, D.H.]]

[[Category: Ohlendorf, D H.]]

[[Category: Prasad, G.S.]]

[[Category: Prasad, G S.]]

[[Category: Radhakrishnan, R.]]

[[Category: Schlivert, P.M.]]

[[Category: Schlivert, P M.]]

[[Category: signal]]

[[Category: superantigen]]

[[Category: toxin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 14:06:~~52 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:50:07 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2tss.gif|left|200px]]<br /><applet load="2tss" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2tss.gif|left|200px]]<br /><applet load="2tss" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2tss, resolution 2.05&Aring;" />
 '''TOXIC SHOCK SYNDROME TOXIN-1 FROM STAPHYLOCOCCUS AUREUS: ORTHORHOMBICC222(1) CRYSTAL FORM'''<br />
 ==Overview==
-The structure of toxic shock syndrome toxin-1 (TSST-1), the causative, agent in toxic shock syndrome, has been determined in three crystal forms., The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between, two symmetry-related molecules. Although not required for biological, activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very, low concentrations. In addition, the structure of the tetramutant TSST-1H, [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify, endotoxin shock, has been determined and refined in a fourth crystal form, (R-factor = 0.173 to 1.9 A resolution).
+The structure of toxic shock syndrome toxin-1 (TSST-1), the causative agent in toxic shock syndrome, has been determined in three crystal forms. The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between two symmetry-related molecules. Although not required for biological activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very low concentrations. In addition, the structure of the tetramutant TSST-1H [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify endotoxin shock, has been determined and refined in a fourth crystal form (R-factor = 0.173 to 1.9 A resolution).
 ==About this Structure==
-TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure superseeds the now removed PDB entry 1TSS. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2TSS OCA].
+TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure supersedes the now removed PDB entry 1TSS. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSS OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Staphylococcus aureus]]
-[[Category: Cook, W.J.]]
+[[Category: Cook, W J.]]
-[[Category: Dinges, M.M.]]
+[[Category: Dinges, M M.]]
-[[Category: Earhart, C.A.]]
+[[Category: Earhart, C A.]]
-[[Category: Mitchell, D.T.]]
+[[Category: Mitchell, D T.]]
-[[Category: Ohlendorf, D.H.]]
+[[Category: Ohlendorf, D H.]]
-[[Category: Prasad, G.S.]]
+[[Category: Prasad, G S.]]
 [[Category: Radhakrishnan, R.]]
-[[Category: Schlivert, P.M.]]
+[[Category: Schlivert, P M.]]
 [[Category: signal]]
 [[Category: superantigen]]
 [[Category: toxin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 14:06:52 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:50:07 2008''