1m85: Difference between revisions
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==Overview== | ==Overview== | ||
A catalase from a peroxide resistant mutant of Proteus mirabilis binds, NADPH tightly. Interestingly, this enzyme can be stripped of NADPH without, loss of the catalatic activity. It is the only known non-mammalian, catalase able to bind NADPH. The structure without cofactor was solved by, molecular replacement using the structure of beef liver catalase as a, model. The structure was refined to an R-factor of 19.3% in the range 8 to, 2.2 A resolution. According to the sequence, a methionine ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7791219 (full description)]] | A catalase from a peroxide resistant mutant of Proteus mirabilis binds, NADPH tightly. Interestingly, this enzyme can be stripped of NADPH without, loss of the catalatic activity. It is the only known non-mammalian, catalase able to bind NADPH. The structure without cofactor was solved by, molecular replacement using the structure of beef liver catalase as a, model. The structure was refined to an R-factor of 19.3% in the range 8 to, 2.2 A resolution. According to the sequence, a methionine sulphone was, positioned in the haem active site. This oxidized form of methionine is, particular to ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7791219 (full description)]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: methionine sulfone]] | [[Category: methionine sulfone]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 11: | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 11:50:06 2007'' | ||
